Regulatory nuclear pathways feeding into the transcription of cancer-relevantmolecules have emerged as the next frontier in pathway-centered cancer therapeutics.The signifi cance of nuclear signaling in cancer is also evident by the convergence ofa large number of signal transduction pathways continuously sensing extracellularmilieu. The cumulative outcome of deregulated cytoplasmic and nuclear signalingis to provide a favorable environment for a cancer cell to survive by overriding deathsignals ...